Which immunologic finding is most typical of primary biliary cirrhosis?
A) Antinuclear antibodies
B) Antismooth muscle antibodies
C) Antimitochondrial antibodies
D) Antimicrosomal antibodies
E) Antinucleolar antibodies

Question

Quizplus · Accepted Answer

Antimitochondrial antibodies (AMA) are present in over 95% of patients with primary biliary cirrhosis (PBC). They are not typically seen in other liver diseases. AMA target enzymes in the mitochondria of cells lining the small bile ducts, leading to destruction of these cells and scarring of the liver over time. AMA testing is a useful diagnostic tool for PBC.

Which Immunologic Finding Is Most Typical of Primary Biliary Cirrhosis