In humans, a mutation in the phenylalanine hydroxylase gene causes phenylketonuria (PKU), which is characterized by a wide variety of medical problems. This is an example of epistasis.

Question

Quizplus · Accepted Answer

Phenylketonuria (PKU) is caused by a mutation in a single gene (phenylalanine hydroxylase), which directly leads to the condition without the interaction of multiple genes, thus it is not an example of epistasis. Epistasis involves the interaction of multiple genes to affect a single trait.

In Humans, a Mutation in the Phenylalanine Hydroxylase Gene Causes