The concerted and sequential models for the behavior of allosteric enzymes differ in
A) the conformational change in the enzyme in one model and not in the other.
B) the number of predicted binding sites on the enzyme.
C) the manner in which changes in quaternary structure take place.
D) the response of the enzyme to changes in temperature.

Question

Quizplus · Accepted Answer

The concerted model (proposed by Monod, Wyman, and Changeux) suggests that all subunits of an allosteric enzyme change their conformation simultaneously and in a cooperative manner, while the sequential model (proposed by Koshland, Nemethy, and Filmer) suggests that subunits can change conformation one at a time in response to ligand binding, indicating a difference in how changes in quaternary structure occur.

The Concerted and Sequential Models for the Behavior of Allosteric