T cell receptors that do not interact at all with self-peptide-MHC complexes during T cell development in the thymus normally undergo …
A) positive selection.
B) negative selection.
C) receptor editing.
D) clonal suppression.
E) "death by neglect."

Question

Quizplus · Accepted Answer

Such receptors are useless without the ability to bind to self MHC proteins in complex with peptides. The thymocyte harboring the receptor fails to receive survival signals and dies.

T Cell Receptors That Do Not Interact at All with Self-Peptide-MHC