Which of the following is correct regarding neuronal self-avoidance in both invertebrates and vertebrates?
A) They both rely on alternative splicing to generate the diversity required to uniquely identify each neuron.
B) They both result in tiling, in which not more than one neuron occupies a certain territory.
C) They both rely on protocadherins.
D) They both use a strategy in which homophilic recognition results in avoidance.
E) All of the above.

Question

Quizplus · Accepted Answer

Despite employing similar strategies for self-avoidance, neurons in vertebrates and invertebrates use different cell-surface molecules to distinguish self from non-self. DSCAM proteins in Drosophila can be produced from an extraordinary large number of different isoforms generated by alternative RNA splicing. The protocadherins in vertebrates are expressed in a large number of different combinations. In both examples, homophilic recognition results in self-avoidance. This is distinct from the phenomenon of tiling, where each neuron occupies a solitary territory, repelling its neighbors.

Which of the Following Is Correct Regarding Neuronal Self-Avoidance in Both