Stable β-sheet aggregates can form from many proteins, forming intertwined cross-beta strands that have the potential to kill cells or damage tissues. Which of the following is NOT true regarding these aggregates?
A) They form almost exclusively in the cells of the nervous system.
B) Different types of such aggregates can form from the same protein.
C) Their formation is associated with conditions such as Parkinson's disease and Kuru.
D) They can form spontaneously, but also can be triggered to form by an infection with the same aggregate.
E) Some healthy cells form these aggregates to store their secretory proteins.

Question

Quizplus · Accepted Answer

The amyloid fibrils can occur in many tissues, but the nervous system is the most sensitive to their formation and shows the most symptoms when affected. Studies in yeast cells have shown that different types of infectious prions can form from the same type of protein. Although these aggregates are associated with some diseases in humans, healthy cells are known to use them as well, for storage of secretory proteins for example.

Stable β-Sheet Aggregates Can Form from Many Proteins, Forming Intertwined