Which of the following statements correctly describes Archibald Garrod's hypothesis for how "inborn errors of metabolism" such as alkaptonuria occur?
A) Metabolic enzymes require vitamin cofactors, and affected individuals have significant nutritional deficiencies.
B) Enzymes are made of DNA, and affected individuals lack DNA polymerase.
C) Certain metabolic reactions are carried out by ribozymes, and affected individuals lack key splicing factors.
D) Genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.

Question

Quizplus · Accepted Answer

Archibald Garrod proposed that "inborn errors of metabolism" like alkaptonuria occur because individuals have genetic defects that result in the absence of specific enzymes necessary for normal metabolism. This was one of the earliest insights into the relationship between genes and enzymes.

Which of the Following Statements Correctly Describes Archibald Garrod's Hypothesis