What is a common mechanistic feature of kinases?
A) Phosphoryl groups are transferred from a substrate with high phosphoryl-transfer potential to AMP.
B) Binding of substrate causes a large conformation change that results in cleft closing.
C) All phosphorylation reactions are specific for monosaccharides.
D) Phosphorylation always uses ATP as a substrate.
E) None of the answers is correct.

Question

Quizplus · Accepted Answer

Kinases often undergo a significant conformational change upon substrate binding, which typically involves the closing of a cleft around the substrate. This change is crucial for the enzyme's catalytic activity, allowing it to properly position and modify the substrate.

What Is a Common Mechanistic Feature of Kinases