Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, known as hemoglobin Lepore, is known in the human population. Hemoglobin Lepore has a deleted set of amino acids. If it was caused by unequal crossing over, what would be an expected consequence?
A) If it is still maintained in the human population, hemoglobin Lepore must be selected for in evolution.
B) There should also be persons born with, if not living long lives with, an anti-Lepore mutation or duplication.
C) Each of the genes in the hemoglobin gene family must show the same deletion.
D) The deleted gene must have undergone exon shuffling.
E) The deleted region must be located in a different area of the individual's genome.

Question

Quizplus · Accepted Answer

If the hemoglobin Lepore mutation was caused by unequal crossing over, one sister chromosome would have a deletion and the other would have a duplication. This means that there could be individuals with an anti-Lepore mutation or duplication.

Unequal Crossing Over During Prophase I Can Result in One