Why does targeting glucocerebrosidase to lysosomes in macrophages serve as a treatment for Gaucher's disease?
A)Glucocerebrosidase is normally denatured in the lysosomes.
B)Glucocerebrosidase is delivered to the precise sites in the cell where the deficiency is manifested, correcting the deficit.
C)Glucocerebrosidase denatures the cytoplasm from its location in the lysosomes, correcting the deficit.
D)Glucocerebrosidase binds to the outer lysosome surface and breaks down glycogen in the cytoplasm.
E)Glucocerbrosidase is supposed to digest most of the enzymes in the lysosome.

Question

Quizplus · Accepted Answer

Gaucher's disease is characterized by a deficiency in the enzyme glucocerebrosidase, which normally breaks down a type of fat called glucocerebroside. This leads to the accumulation of glucocerebroside in lysosomes of macrophages, causing organomegaly, anemia and decreased bone density. Targeting glucocerebrosidase to lysosomes in macrophages is a treatment for Gaucher's disease because it delivers the enzyme to the precise site in the cell where the deficiency is manifested, correcting the deficit. In this way, it helps to reduce the buildup of glucocerebroside in macrophages, alleviating the symptoms of the disease.

Why Does Targeting Glucocerebrosidase to Lysosomes in Macrophages Serve as a Treatment