What is responsible for deactivating glycogen synthase kinase-3?
A)phosphorylation by PKB
B)dephosphorylation by protein phosphatase 1
C)dephosphorylation by PKB
D)phosphorylation by protein phosphatase 1
E)degradation by PKB

Question

Quizplus · Accepted Answer

Glycogen synthase kinase-3 (GSK-3) is deactivated by phosphorylation by protein kinase B (PKB), also known as AKT. Phosphorylation of GSK-3 at Ser9 or Ser21 by PKB inhibits its activity towards its substrates.

What Is Responsible for Deactivating Glycogen Synthase Kinase-3