What happens to T cells whose TCRs are unable to recognize self-MHC complexes?
A)They die within the thymus due to a lack of growth signals.
B)They die within the bone marrow due to a lack of growth signals.
C)They undergo proliferation in the thymus.
D)They undergo proliferation in the bone marrow.
E)They remain quiescent until further growth factors stimulate their proliferation.

Question

Quizplus · Accepted Answer

T cells whose TCRs are unable to recognize self-MHC complexes undergo negative selection in the thymus, which results in their apoptosis (death) due to a lack of survival and growth signals. This eliminates potentially harmful T cells that could cause autoimmune reactions.

What Happens to T Cells Whose TCRs Are Unable to Recognize