Attachment of HIV to the target cell depends on
A) gp41 binding to the CD4+ receptor.
B) gp120 combining with the chemokine receptor CCR5.
C) CXCR4 binding to the CD4+ receptor.
D) gp120 binding to the CD4+ plasma membrane.
E) gp120 combining with the CD4+ receptor.

Question

Quizplus · Accepted Answer

gp120 binds to the CD4+ receptor, which is expressed on the surface of helper T cells. This binding event triggers a conformational change in gp120, which allows gp41 to bind to the chemokine receptor CCR5 or CXCR4. This binding event allows the virus to enter the cell.

Attachment of HIV to the Target Cell Depends on