What would be the consequence of a loss of 3'-to-5' exonuclease activity?
A) A 100-fold increase in apyrimidinic sites.
B) A 100-fold increase in spontaneous mutation frequency.
C) A 100-fold decrease in base excision repair.
D) A 100-fold increase in induced mutation frequency.
E) A 100-fold increase in trinucleotide repeats.

Question

Quizplus · Accepted Answer

A loss of 3'-to-5' exonuclease activity would result in a 100-fold increase in spontaneous mutation frequency because this activity is a key component of DNA proofreading and repair mechanisms. Without it, there would be a higher likelihood of errors and mutations occurring during DNA replication. The other choices are not directly related to this specific function.

What Would Be the Consequence of a Loss of 3'-To-5