What is the role of inactive MLH1 in the development of some forms of inherited colon cancer?
A) Deletion of a nucleotide repeat in the DUX4 gene.
B) DNA damage is left unrepaired.
C) Expansion in the number of cytosine-guanine (CG) dinucleotide.
D) Abnormalities of chromosome 11p15.5 that lead to downregulation of IGF2.

Question

Quizplus · Accepted Answer

Inactive MLH1 leads to a failure in the DNA mismatch repair system, resulting in DNA damage being left unrepaired, which can contribute to the development of inherited colon cancer.

What Is the Role of Inactive MLH1 in the Development