What do you predict would be the effect of an inversion of the β-globin gene cluster with respect to the LCR?
A)No globin genes will be expressed and the fetus will die in utero.
B)ε-globin will be expressed first during development.
C)The order of globin gene expression will be reversed; the effect on the fetus cannot be predicted.
D)The individual will develop sickle-cell disease in adult life.

Question

Quizplus · Accepted Answer

The Locus Control Region (LCR) is crucial for the proper expression of the globin genes in a developmental stage-specific manner. An inversion of the β-globin gene cluster with respect to the LCR could disrupt the normal spatial and temporal expression of these genes, potentially reversing the order in which they are expressed. However, the specific effect on the fetus would depend on the nature of the inversion and how it affects gene expression, making it unpredictable.

What Do You Predict Would Be the Effect of an Inversion