Figure 7.1
-How would you predict that blocking the oxidation of pyruvate would affect the levels of oxaloacetate and citrate in the citric acid cycle (see Figure 7.1)?
A)There will be no change in the levels of oxaloacetate and citrate.
B)Oxaloacetate will decrease,and citrate will accumulate.
C)Oxaloacetate will accumulate,and citrate will decrease.
D)Both oxaloacetate and citrate will decrease.
E)Both oxaloacetate and citrate will accumulate.

Question

Figure 7.1
-How would you predict that blocking the oxidation of pyruvate would affect the levels of oxaloacetate and citrate in the citric acid cycle (see Figure 7.1)?
A)There will be no change in the levels of oxaloacetate and citrate. 
B)Oxaloacetate will decrease,and citrate will accumulate. 
C)Oxaloacetate will accumulate,and citrate will decrease. 
D)Both oxaloacetate and citrate will decrease. 
E)Both oxaloacetate and citrate will accumulate.

Quizplus · Accepted Answer

Blocking the oxidation of pyruvate prevents the formation of acetyl-CoA, which is necessary for citrate synthesis. This leads to a decrease in citrate levels and an accumulation of oxaloacetate, as it is not being used to form citrate.

Figure 7.1 -How Would You Predict That Blocking the Oxidation of Pyruvate