Injectable drugs are tested for endotoxins by
A) filtering out the cells.
B) looking for turbidity.
C) culturing bacteria.
D) counting the viable bacteria.
E) the Limulus amoebocyte lysate test.

Question

Quizplus · Accepted Answer

The Limulus amoebocyte lysate (LAL) test is widely used to detect endotoxins in injectable drugs. LAL is a sensitive assay that uses horseshoe crab blood cells to detect the presence of endotoxins. The clotting reaction between LAL and endotoxin is detected by a spectrophotometer, and the level of endotoxin can be quantified. This method is considered a reliable and specific test for endotoxins in pharmaceutical products.

Injectable Drugs Are Tested for Endotoxins by