What is one drawback of next- generation sequencing?
A) Next- generation sequencing works best on eukaryotic DNA.
B) Next- generation sequencing can only be used to sequence whole genomes.
C) Next- generation sequencing is slower than Sanger sequencing.
D) Next- generation sequencing has difficulty sequencing DNA with repetitive sequence.
E) Next- generation sequencing is more expensive than Sanger sequencing.

Question

Quizplus · Accepted Answer

One drawback of next-generation sequencing is that it has difficulty sequencing DNA with repetitive sequence. This is because the short reads generated by next-generation sequencing cannot always be accurately aligned to repetitive regions of the genome, leading to gaps or errors in the final sequence assembly.

What Is One Drawback of Next- Generation Sequencing