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Traditional ______1______ diagnosis has involved _____2______ surgical procedures in which a sample of fetal cells is recovered and analysed. There have been two major approaches. In one case a sample is taken from the _____3____ (the outermost extra-embryonic ____4_____ ). Typically this sample is taken in the ____5______ trimester of pregnancy. In the other case, a sample of _____6_____ fluid is taken that will contain cells from the _____7______ , an inner extra-embryonic ____4_____. This procedure, called ____8_____ is taken at, or close to, 16 weeks of gestation; it provides fetal cells that can be processed to allow ____9_____ analyses as well as DNA analyses. Because of the surgical procedures involved there is a small excess risk of ____10_____. As a result, there has been a trend to develop non-_____2______ ______1______ diagnosis. That has been fuelled by _____11_______ ______12______ sequencing of DNA from maternal ____13____.
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