Which mutations can interfere with the proper insertion of a protein in the plasma membrane?
A)A polar amino acid to a nonpolar amino acid within a transmembrane domain
B)A nonpolar amino acid to a polar amino acid within a transmembrane domain
C)A polar amino acid to a nonpolar amino acid within a cytoplasmic domain
D)A nonpolar amino acid to a polar amino acid within a cytoplasmic domain

Question

Quizplus · Accepted Answer

Transmembrane domains are composed of nonpolar amino acids that interact with the hydrophobic regions of the plasma membrane. A mutation from a nonpolar to a polar amino acid within a transmembrane domain would disrupt this interaction and prevent proper insertion into the plasma membrane. Mutations in cytoplasmic domains would not affect the insertion of a protein into the membrane.

Which Mutations Can Interfere with the Proper Insertion of a Protein