The gene encoding apolipoprotein B exists in two isoforms,APOB100 and APOB48.These two forms are produced as a result of
A)tissue-specific expression.
B)a gene mutation that results in a stop codon.
C)RNA editing.
D)alternative splicing.

Question

Quizplus · Accepted Answer

APOB100 and APOB48 are produced from the same gene through a process called RNA editing. In this process, a specific cytidine nucleotide in the APOB mRNA is deaminated to uridine, creating a stop codon that results in the shorter APOB48 isoform. This editing occurs in the intestine, leading to the production of APOB48, while the liver produces the full-length APOB100.

The Gene Encoding Apolipoprotein B Exists in Two Isoforms,APOB100 and APOB48.These