Describe the apoptotic pathway in mammalian cells.
A)Apaf1 inhibits Bcl2,Caspase-8 or 9 is activated,caspases degrade cell components
B)Bcl2 activates Apaf1,Caspase-8 or 9 is inhibited,caspases degrade cell components
C)Apaf1 activates Bcl2,Caspase-8 or 9 is activated,caspases degrade cell components

Question

Quizplus · Accepted Answer

Apaf1 does not inhibit Bcl2; instead, it is involved in the activation of caspase-9, leading to the activation of other caspases that degrade cell components. Bcl2 actually acts to inhibit apoptosis by preventing the release of cytochrome c, which is necessary for Apaf1 activation.

Describe the Apoptotic Pathway in Mammalian Cells