Through the study of mitochondrial disorders,scientists have suggested a link between the decline of mitochondrial function and aging.What process appears to be involved in this suspected phenomenon?
A)decline of mutations in the nuclear genome
B)accumulation of mutations in the mtDNA
C)recombination among mtDNAs of different mitochondria
D)recombination of mtDNA and nuclear DNA
E)accumulation of sporadic mutations in the nuclear genome

Question

Quizplus · Accepted Answer

The accumulation of mutations in mtDNA appears to be involved in the suspected phenomenon of the decline of mitochondrial function and aging. This is because mtDNA is particularly vulnerable to mutations due to its close proximity to reactive oxygen species generated during oxidative phosphorylation. Over time, these accumulated mutations can impair the ability of the mitochondria to produce energy efficiently, leading to age-related declines in physiological function.

Through the Study of Mitochondrial Disorders,scientists Have Suggested a Link