The regulation of the sleep-wake cycle has been linked to phenylalanine hydroxylase.

Question

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Phenylalanine hydroxylase is an enzyme involved in the metabolism of the amino acid phenylalanine, and its deficiency leads to the accumulation of phenylalanine in the body causing a condition called phenylketonuria (PKU). While sleep-wake cycle regulation is influenced by various neurotransmitters such as serotonin, dopamine, and melatonin, there is no direct link established between phenylalanine hydroxylase and the sleep-wake cycle.

The Regulation of the Sleep-Wake Cycle Has Been Linked to Phenylalanine